The life science group Sartorius at the BioProcess International 2022 conference the launch of Sartobind® Rapid A, a ready-to-use, disposable membrane for monoclonal antibody (mAb) capture.
Biopharmaceutical partners who use packed bed chromatography for mAb capture typically suffer from low productivity, higher costs, and laborious operations.
Sartorius’ membrane will trigger a paradigm shift in the mAb capture step by overcoming nearly all the limitations of packed bed chromatography. With Sartobind® Rapid A, Sartorius is bringing a scalable, ready-to-use disposable Protein A membrane to market, offering a true alternative to columns in the mAb capture step.
Sartorius now offers Sartobind® Rapid A for process platform developers and recombinant protein manufacturers looking for more economical, convenient, and reproducible process solutions.
The unique membrane combines the high binding capacity (avg. 40 g/L) of resins and high flow rates (up to 100 cycles per day) of convective chromatography media, resulting in 10-fold higher productivity compared to traditional resin-based processes.
Completing cycles within minutes means lifetime studies can be performed in one day (compared to months), shortening time-to-clinic.
Featuring a one-batch, one membrane approach, Sartobind® Rapid A eliminates extraneous time, resources, and 80% of column handling activities while minimizing bioburden risks associated with the extended reuse of packed bed column chromatography equipment.
In addition, Sartobind® Rapid A is a fully proven scalable solution from process development to commercial scale.
“The introduction of Sartobind® Rapid A changes the game and makes disposable 'plug and play' mAb capture a reality. A unique one-batch, one-membrane approach reduces bioburden risk and lowers COGs compared to resin-based processes.
Plus, rapid cycling translates to >10x higher productivity and linear scalability from PD to commercial scale,” said Louis Villain, Head of Product Group Separation Consumables, Sartorius.
“Ready for use at all scales, from development to commercial manufacturing, is an additional key aspect of the Sartobind® Rapid A solution. Utilizing the capacity during a batch will provide the advantage of minimal validation efforts, consistency from batch to batch, and full scalability.”
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